Prague seems to have an enduring link in people’s minds with vampires. This association is not recent; H.P. Love

craft wrote The case of Charles Dexter Ward in 1927 in which the young protagonist travels to Prague where he unfortunately meets "an evil old man called Josef Nadek" who teaches him the secret knowledge that allows him to bring a vampire back to life from its ashes. Being a Lovecraft story, horror follows horror. Finally, after several warning letters have mysteriously been received from Prague, written in medieval language and referring to magical formulae and incantations, the vampire is finally destroyed.

In many modern horror films there is a mention of Prague as the birthplace of vampires ("John Carpenter’s Vampires" in which the vampire leader is a charismatic figure born in Prague in 1311, is one notable example). Some recent films such as the "Blade" movies have played on this with a Prague setting. Prague has even featured in "Buffy, the vampire slayer" as the place where the vampire couple, Spike and Drusilla, were attacked by an angry mob.

There is some historical basis for all this association with vampirism in the capital of Bohemia. As recent article on Czech radio and the Prague Post explained:

Time and again, archeologists working in the Czech Republic come across what they believe are vampire graves. The skeletons they find have been mutilated using methods that, in the superstition-fueled Middle Ages, were thought to destroy the suckers once and for all. Bodies were exhumed, stakes driven, limbs severed, bones broken…
The most famous of all such graves was discovered in 1966 in Celakovice, 10 kilometers (six miles) northeast of Prague. There, archeologists uncovered 14 skeletons dating from the 10th century. The mouths were filled with stones and sand; the heads were removed from the bodies. Stories began circulating that the skeletons had fangs.